IMGT Repertoire (IG and TR)
Number of germline genes and potential repertoire: Human (Homo sapiens) IGKV at 2p11.2
Distal and proximal V-CLUSTERs (for the haplotypes with both clusters).
- 76 IGKV genes belonging to 7 subgroups, on 1 800 kilobases:
- 34 FUNCTIONAL
- 8 ORF (Open Reading Frame)
- 30 PSEUDOGENE
- 4 FUNCTIONAL or PSEUDOGENE
- Potential repertoire: 34-38 FUNCTIONAL IGKV genes belonging to 5 subgroups
| Subgroup | Functional | ORF | Pseudogene | Total |
|---|---|---|---|---|
| IGKV1 | 17(+2)* | 3 | 7(+2)* | 29 |
| IGKV2 | 9(+1)* | 1 | 16(+1)* | 27 |
| IGKV3 | 6(+1)* | 1 | 6(+1)* | 14 |
| IGKV4 | 1 | - | - | 1 |
| IGKV5 | 1 | - | - | 1 |
| IGKV6 | - | 3 | - | 3 |
| IGKV7 | - | - | 1 | 1 |
| Total | 34(+4)* | 8 | 30(+4)* | 76 |
* FUNCTIONAL or PSEUDOGENE (IGKV1-13, IGKV1-39, IGKV2-29, IGKV3D-15)
Proximal V-CLUSTER (for the haplotypes without the distal V-CLUSTER)
- 40 IGKV genes belonging to 7 subgroups, on 600 kilobases:
- 18 FUNCTIONAL
- 3 ORF (Open Reading Frame)
- 16 PSEUDOGENE
- 3 FUNCTIONAL or PSEUDOGENE
- Potential repertoire: 18-21 FUNCTIONAL IGKV genes belonging to 5 subgroups
| Subgroup | Functional | ORF | Pseudogene | Total |
|---|---|---|---|---|
| IGKV1 | 9(+2)* | 1 | 3(+2)* | 15 |
| IGKV2 | 4(+1)* | - | 9(+1)* | 14 |
| IGKV3 | 3 | 1 | 3 | 7 |
| IGKV4 | 1 | - | - | 1 |
| IGKV5 | 1 | - | - | 1 |
| IGKV6 | - | 1 | - | 1 |
| IGKV7 | - | - | 1 | 1 |
| Total | 18(+3)* | 3 | 16(+3)* | 40 |
* FUNCTIONAL or PSEUDOGENE (IGKV1-13, IGKV1-39, IGKV2-29).
Last updated: Thursday, 10-Jan-2013 22:06:22 CET
Author: Valérie Barbié
Editor: Chantal Ginestoux
Contact: Marie-Paule Lefranc
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References to cite:
Lefranc, M.-P. et al.,
Nucleic Acids Research, 27, 209-212 (1999)
Cover of NAR;
Ruiz, M. et al.,
Nucleic Acids Research, 28, 219-221 (2000);
Lefranc, M.-P.,
Nucleic Acids Research, 29, 207-209 (2001);
Lefranc, M.-P.,
Nucleic Acids Res., 31, 307-310 (2003);
Lefranc, M.-P. et al.,
In Silico Biol., 5, 0006 (2004) [Epub],
5, 45-60 (2005);
Lefranc, M.-P. et al.,
Nucleic Acids Res., 33, D593-D597 (2005)
Full text;
Lefranc, M.-P. et al.,
Nucleic Acids Research 2009 37:
D1006-D1012; doi:10.1093/nar/gkn838
Full text.
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Marie-Paule.Lefranc@igh.cnrs.fr.
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