Print of this table: Pallarès, N. et al., Exp. Clin. Immunogenet., 16, 36-60 (1999). PMID:10087405 UPDATE: Human IGHV (10/2002)

References :

Matsuda et al. J. Exp. Med., 188, 1-15 (1998) and references in Human Germline IGHV gene table

• 123-129 IGHV genes on 900 kilobases : 82-88 IGHV genes belonging to 7 subgroups, 41 pseudogenes assigned to the clans and 7 non-mapped genes.
  • 38-44 FUNCTIONAL
  • 4 ORF (Open Reading Frame)
  • 79 PSEUDOGENE
  • 1 FUNCTIONAL or ORF
  • 1 FUNCTIONAL or PSEUDOGENE

• Potential repertoire : 38-46 FUNCTIONAL IGHV genes belonging to 6 or 7 subgroups

Subgroup	Functional	ORF	Pseudogene	Total
IGHV1	9	-	5	14
IGHV2	3	-	1	4
IGHV3	18-20**(+1)*	3	25(+1)*	47-49**
IGHV4	6-9**(+1)*	(+1)*	2	9-12**
IGHV5	1	-	1	2
IGHV6	1	-	-	1
IGHV7	0-1**	1	4	5-6**
IGHV(II)	-	-	22	22
IGHV(III)	-	-	18	18
IGHV(IV)	-	-	1	1
Total	38-44(+2)*	4(+1)*	79(+2)*	123-129**

* An asterisk indicates that the following genes have alleles with different functionality:
FUNCTIONAL or PSEUDOGENE (IGHV3-11)
FUNCTIONAL or ORF (IGHV4-61).

** Two asterisks indicate allelic polymorphisms by insertion/deletion which concern:
    - a 50 kb insertion of 5 genes (3-30-5, 4-30-4, 3-30-3, 4-30-2, 4-30-1) in 45 % Caucasoïdes
    - the IGHV7-4-1 gene.

II, III, IV (in parentheses) refer to the clans, for the pseudogenes which could not be assigned to subgroups with functional genes. All these pseudogenes have truncations. Clans comprise, respectively:
- clan I: IGHV1, IGHV5 and IGHV7 subgroup genes
- clan II: IGHV2, IGHV4 and IGHV6 subgroup genes, and pseudogenes IGHV(II)
- clan III: IGHV3 subgroup genes, and pseudogenes IGHV(III)
- clan IV: one pseudogene IGHV(IV)-44.

The 7 non-mapped genes are not included in this table, 3 of them are functional (1-f, 3-d, 4-b), 1 is functional (5-a), 1 is ORF (1-c), 1 is a pseudogene (3-g), and the last one (3-h) too partial to determine its functionality.

Created: 09/04/1997
Last updated: Friday, 29-Jul-2011 22:30:31 CEST
Authors: Dominique Scaviner, Nathalie Pallarès, Marie-Paule Lefranc
Contact: Marie-Paule Lefranc

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